SLENTR°L
dirlotapide
Oral soltlon lor use ir dais oily.
CAUTION Federal (USA| imv restricts fis dug to use t'/ o on ihc order <4 a keens«
veterinarian.
INDICATIONS: SLENTROL (dutfasiJel OralSouKn isirdcaUad for tie man?gcrr>.->i'
ot obesity n dogs
CONTRAINDICATIONS: SLENTROL ihoUd not te used In cats. SLEN1HOL increases
the risuot pi oduong hepatic Iprfosis during weight loss motes* cats SLENTROL is
not recommended tor use in dngsoirrertty recevinj orQ-term coilcostcroid toerfpy
Do not use n dags mitli if.« disease.
WARNINGS: Not tor *se in humans. Keep Bits and all drugs out ot reach ot children
Adverse reactions associated with humans ingesting dirlotapide include abdcminal
distention, abdominal pain, diarrhea, flatulence, headache, increased serum
transamitasrs. nausea, and vomiting
SLENTROL iroy raise e»C-iirilation It accidenlal
ir/i;
eiposure occurs f ish toe eyes
immediatety with clean water
PRECAUTIONS: Safety in breecing. pregnant or lactation dogs has not been
establsfird. Caution should be taken »he* considering any «eight to s piogram in
growing dogs including treatment win SLENTROL SLENTROL has not been e.oUited
m dogs less than t year or aje
AJi dogs should undergo a thorough history and physical examination that inckudss
taboratcry tests to screen to- underlying condit ore. Pre-existing endeerme disease,
«atludnghyparadreralcomcalisn (Cushing's dooase). should be managed pror to
use ot SLENTROL.
SLENTROL iray produce a mild tc moderate elevation m scrum hepatic Iransamirase
activity It the elevation in alanine airiixcrarsfcrase (ALT) activity is mild, continue
SLENTROL and non lo r
a
meded. If there Is a martred elevation in ALT activity
atone th? normal retererce range or there is a simultaneous increase in aspartate
annotransferase(AST). alkaline phosphatase (ALP), y-glutamyl transferase <6GT).
or total bihnutin, discor.tnue treatment rath SLENTROL. Etevatons in negate
transaminaseactnvty usually decrease when SLENTROL « discontinued.
The safety ot SLENTROL us« in dogs has not beer evaluated beyond 1 year.
AOVERSE REACTIONS:
Th? adverse reactions associated with treatment with SLENTROL include vomiting,
toes« stools'diarifKa. lethargy, aid anorexia. These adverse reactions were mainly
observed during ire tirsi month ot treatment or dunng the ween alter a dcse « ra s e
Vanning was usuaty mid In se.ority. ot short duration, and resohod wth continued
SLENTROL treatment The SLENTROL-treated decs otneraby had an uxieased
frequency and duraton ol vomtng and diarrhea compared to ttae control dogs. The
« .« m il nogs teuovutf cum ml.
Adverse Reactions Ourug Weight loss:
Treatment
Percentage ol Patients w th Reported Signs
Control
n>88
SLENTROL
n -170
Vomitirg
21.6%
247%
Diarrhea
6.8%
12 4%
Lethargy
3.4‘ .
9.4%
Anorexia
2.3%
7.6%
Constipation
1.1%
2.4%
Dehydration
0%
1.2%
In addition to lie adierst reactions Isied above, there were oner abnormal findings.
Many control and SlENTROL-treated dogs had dental disease, abnormal skin and
ear t *dings, and tameness/arthritls The incidence of these findings »we similar in
both conlrot and SLENTROL-treated Q'Cups and most degs had simila- lesom ranted
pre-trealliiKiil. Two (toys in the SLENTROL I real: rent group developed corneal takers
Ore St FNTROI -treated w d one control dag dembped sgns consistent with pancreatitis
One treated Cog developed inappropriate urination and defecatcm and another treated
dog oevacpei polyuria aid potyw ia
A 5-year-c<d Beapte with no medical history ol secures in the SLENTROL treatment
group had a seizure on Day 52 cr the study The dog continued to receive SLENTROL
until additional $
4
bines « tu rre t
11
and 1? cays later. The investigator referred the
case to a neurologist and the seirures continued approximately twice week!/. Tne
neurologist found no lesions lhal suppo-t Hie ciusaKy ot he secures.
A 5-ycar-cfd Dachshund dewoped
1
hepatopathy alter 82 days of treatment and was
withdrawn trom the study ton vomiting. Increased hepatic enzymes, and anorexia
Vomibng rant rued tor a tew days after swpprg treatment and tie dog was hospiutzed
due to thr anore>la. ALT actl.Wy levels continued to hse alter ail cir.ca observations
resolved.
During weight stabilization vomiting (t6 1%) and lethargy (4 8*.
1
were the most
frequent adverse reactions assccialtd with treatment with SLENTROL Olher adve-se
reactions induced darroa (1.6%). anorexia |16*.>l. anoaraxu (
1
6%).
In the posl-treatraem peiicd a 6 ye» oat spayed lenale Chituxiliui. was found dead
by the owner 7 days after stepping riirkcapilc therapy. The cause ot death ivas net
ccndusiiv but did not appear to be -dared to the dirlotapide therapy
Some dogs treated with SLENTROL displayed a m ill to moderate elevation in senna
hepatic transanrase aetwity eary n treatment that decreased o/er ime whip treabnert
continued. Hepatic transaminases generally returned to normal -M*jh tealment was
discontinued (See Precautions for turilier irformation).
Serum Chemistry Results:
Puree stag? ot Dogs
Cottrd
SLENTROL
n .8 B
n> 170
Serum
Aialyte
Pre к
Рой'
Pre*
Post*
ALP > 150IU1
3.4%
60%
47%
99%
ASTb>60 IUiL
0%
4.8%
3 5%
9 2%
AIPS >125 IU1
11 4%
16 9%
17 6%
9 9%
Cttfeslerol >320 mg'dl
14.8%
9.6%
14.7%
46%
a ALT - serum aJanm: aninctransterase activity.
b ASI = serwnasparateamnotransteraseactmty
c ALR = serum akairvc pnosphalasr activity. Uogs with ALRactivity >325 IU L were
excluded from the study.
11
Pre - 4 o f dega wtn values above the laboratory reference range at pre-ireaimev
e Post * S ot dogs with values chow the laboratory refrrence ranga after a mcnihs
ot treatment.
To report a suspected adverse reaction call Plirer Aninal Health at 1 8M 3E6 5288.
For a copy ottbe Material Safety Data Sheet (MSDS) lor SLENTROL oral solution
call 1-800-733-5500.
STORAGE INFORMATION;
Store in crigrnal lorrtbner at гост temperature 15* to 30* C (59‘ to 86" F).
HOW SUPPLIED:
SLENTROL isavalatte in 20.50and 150 mL bottles containing 5 ngrtnL
ol dirlotapide m solution
US Patent No 6.720.351
NADA a 141-260. Approved Cy FDA
IT i/.t r A n iin u l llr n lili
Or# ol
Inc
Wf.HY ТЮ17
820 ©X) OOO
October 2008
Bench warmer
“I love benches
for their versatility,” Stephen says. “I use
them as coffee tables, an alternative to a
bookshelf, and extra seating.”
In this breakfast room, Stephen wanted
a place for display, but had to work around
minimal wall space. The bench was a
perfect solution, offering a low surface for
books, art, and fruit. The space-savvy fix
still leaves room for a magazine rack and
message center, hung directly on the
window trim.
1
®
M ORE AT
BH G .CO M
See behind-the-
scenes pictures
of this makeover
and others.
BHG.com/
Stephen
makeovers
For buying information see page 232.
5 0
JUNE 2008 BETTER HOMES AND GARDENS
